Parathyroid hormone inhibitors. Determination of minimum sequence requirements.
نویسندگان
چکیده
منابع مشابه
Bovine parathyroid hormone: amino acid sequence.
Bovine parathyroid hormone has been isolated in homogeneous form, and its complete amino acid sequence determined. The bovine hormone is a single chain, 84 amino acids long. It contains amino-terminal alanine, and carboxyl-terminal glutamine. The bovine parathyroid hormone is approximately three times the length of the newly discovered hormone, thyrocalcitonin, whose action is reciprocal to par...
متن کاملBiosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells.
Preproparathyroid hormone (prepro-PTH) is one of the proteins abundantly synthesized by parathyroid chief cells; yet under normal growth conditions, little or no prepro-PTH can be detected in these cells. Although this may be attributed to effective cotranslational translocation and proteolytic processing, proteasome-mediated degradation of PTH precursors may be important in the regulation of t...
متن کاملDetermination of parathyroid hormone levels in fine needle aspirates of ectopic parathyroid glands.
Sir, Progressive image technologies are improving the accuracy for determining the localization of enlarged parathyroid glands (PTGs) in hyperparathyroidism (HPT). However, the identification of an unusually located cervical nodule as an ectopic PTG remains uncertain. The measurement of parathyroid hormone (PTH) in the aspirated material with a fine needle has shed light on this diagnostic diff...
متن کاملParathyroid hormone without parathyroid glands.
In mammals, PTH is a component in a complex signaling system involving three structurally related ligands and two G protein-coupled receptors, which share significant amino acid sequence homology (Fig. 1). PTH is a peptide hormone comprising 84 amino acids that is made by the parathyroid glands (and to a much smaller extend by the thymus) and acts through the PTH/PTH-related peptide (PTHrP) rec...
متن کاملPTHLH (parathyroid hormone-like hormone)
DNA/RNA Description PTHLP is encoded by a single gene that is highly conserved among species. The gene is composed of 7 exons spanning a region of 13,899 bases (Start: 28,002,284 bp from pter; End: 28,016,183 bp from pter). Orientation: minus strand. The genomic DNA for the PTHLP gene was isolated from a human placental genomic library. Transcription The sequence is supported by 3 sequences fro...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1979
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)50395-1